A genome-wide CRISPR/Cas9 knockout screen identifies TMEM239 as an important host factor in facilitating African swine fever virus entry into early endosomes.
African Early Learning Toy swine fever (ASF) is a highly contagious, fatal disease of pigs caused by African swine fever virus (ASFV).The complexity of ASFV and our limited understanding of its interactions with the host have constrained the development of ASFV vaccines and antiviral strategies.To identify host factors required for ASFV replication